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Drug Interactions With Atorvastatin

Digoxin (Digitek, Lanoxin)
Atorvastatin can increase digoxin levels in the blood, possibly increasing the risk of serious side effects. Your healthcare provider should monitor the level of digoxin in your blood, especially when you start or stop atorvastatin.
 
Diltiazem
Diltiazem can increase the level of atorvastatin in your blood, increasing your risk of side effects. Check with your healthcare provider before taking these medications together.
 
Efavirenz (Sustiva)
Efavirenz may decrease the level of atorvastatin in your blood, perhaps making it less effective. Your healthcare provider may need to increase your atorvastatin dosage to prevent this drug interaction from occurring.
 
Fibrates
Taking a fibrate and atorvastatin at the same time may increase your risk of serious muscle problems, such as myopathy or rhabdomyolysis (see Lipitor and Muscle Pain). Check with your healthcare provider before taking these medications together (see Lipitor and Lopid Warning for more information).
 
Grapefruit Juice
Grapefruit juice can increase the level of atorvastatin in your blood, increasing your risk of dangerous side effects. It is best to avoid grapefruit juice altogether while you are taking atorvastatin. If you are taking this medication and want to continue eating grapefruit or drinking grapefruit juice, talk to your doctor about other cholesterol medications you can take (see Lipitor and Grapefruit for more information).
 
Niacin (Nicotinic Acid, Niacor, Nicolar)
Combining niacin with atorvastatin may increase the risk of serious muscle problems, such as myopathy or rhabdomyolysis (see Lipitor and Muscle Pain). Do not combine these medications without your healthcare provider's approval (see Lipitor and Niacin).
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Atorvastatin Calcium

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