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Drug Interactions With Artemether/Lumefantrine

When birth control pills, certain beta blockers, and grapefruit juice are taken with artemether/lumefantrine, drug interactions may occur. These reactions can alter the level of the medications in your blood and increase your risk of potentially dangerous side effects. To help reduce your risk for complications, make sure to tell your healthcare provider if you are taking any other medications before starting treatment with this antimalarial drug.

An Overview of Artemether/Lumefantrine Interactions

Artemether/lumefantrine (Coartem®) is a prescription medication licensed to treat malaria infections. This medication may potentially interact with many other products.
Some of the medications that may lead to artemether/lumefantrine drug interactions include but are not limited to:
  • Anti-retroviral HIV medicines, such as:
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV medications, such as:
  • CYP 3A4 inhibitor medications, such as:
    • Amprenavir (Agenerase®)
    • Atazanavir (Reyataz®)
    • Clarithromycin (Biaxin®)
    • Conivaptan (Vaprisol®)
    • Darunavir (Prezista®)
    • Delavirdine (Rescriptor®)
    • Erythromycin
    • Fosamprenavir (Lexiva®)
    • Imatinib (Gleevec®)
    • Indinavir (Crixivan®)
    • Isoniazid
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Lopinavir and ritonavir (Kaletra®)
    • Miconazole
    • Nefazodone (Serzone®)
    • Nelfinavir (Viracept®)
    • Nicardipine (Cardene®)
    • Posaconazole (Noxafil®)
    • Quinidine
    • Ritonavir (Norvir®)
    • Saquinavir (Fortovase®, Invirase®)
    • Telithromycin (Ketek®)
    • Voriconazole (VFEND®)

Artemether/Lumefantrine Drug Information

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