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Drug Interactions With Artemether/Lumefantrine

Codeine Pain Medications
Artemether/lumefantrine can make codeine less effective at controlling pain. If you are taking codeine and artemether/lumefantrine together, your healthcare provider will monitor your response to codeine. Tell your healthcare provider if your pain is not adequately controlled, as you may need a different pain medication.
 
Strong CYP 3A4 Inducers
The body breaks down artemether/lumefantrine using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining artemether/lumefantrine with a CYP 3A4 inducer may decrease the level of artemether/lumefantrine in your body, making it less effective.
 
Different medications induce CYP 3A4 to different extents. Strong CYP 3A4 inducers should not be combined with artemether/lumefantrine, due to the strong likelihood that they will make artemether/lumefantrine significantly less effective.
  
CYP 3A4 Inhibitor Medications
The body breaks down artemether/lumefantrine using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining artemether/lumefantrine with one of these CYP 3A4 inhibitors may increase the level of artemether/lumefantrine in your body, increasing your risk for serious side effects. Your healthcare provider may monitor you more closely for side effects if you take artemether/lumefantrine with a CYP 3A4 inhibitor.
 
Dapsone
Taking artemether/lumefantrine with dapsone can increase the risk for serious blood reactions. This risk is probably highest in people who have certain blood conditions, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, methemoglobin reductase deficiency, or hemoglobin M. If you have one of these conditions, you should discuss this reaction with your healthcare provider before starting artemether/lumefantrine treatment. If you do take these medications together, your healthcare provider may need to closely monitor you for blood reactions.

Artemether/Lumefantrine Drug Information

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