Arcalyst Mechanism of Action

Available by prescription only, Arcalyst® (
 rilonacept) is used to treat a group of rare genetic conditions called cryopyrin-associated periodic syndromes (CAPS). These conditions cause inflammation in the body, and include Muckle-Wells syndrome (MWS) and familial cold autoinflammatory syndrome (FCAS). This medication is a type of interleukin-1 beta (IL-1β) blocker.
 
Arcalyst works by blocking the actions of interleukin-1 beta (IL-1β), which is a protein in the immune system that causes inflammation in the body. People with CAPS have increased levels of IL-1β, which leads to inflammation in the body. By blocking the action of IL-1β, Arcalyst reduces CAPS symptoms.
 
(To learn more about the mechanism of action for this drug, click Arcalyst. This article offers a complete overview of this medication, including how it works, general safety precautions to be aware of, and tips for using it properly.)
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD