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What Is Aprepitant Used For?

Aprepitant for Chemotherapy Nausea and Vomiting

Nausea and vomiting are common side effects of chemotherapy. Some types of chemotherapy are more likely to cause nausea and vomiting than others. Nausea and vomiting from chemotherapy are likely due to many causes.
The main symptoms of nausea are feeling sick to your stomach and feeling like you might vomit, while vomiting is actually "throwing up." In general, aprepitant is better at preventing vomiting than preventing nausea. It is much easier to prevent nausea and vomiting than to treat it once it starts. Aprepitant is licensed to prevent nausea and vomiting, but it is not a treatment for vomiting or nausea.
Aprepitant should always be used in conjunction with other medications to prevent nausea and vomiting due to chemotherapy. The nausea medicine chosen by your healthcare provider for this purpose will depend on several factors, including the type of chemotherapy and your previous experiences of nausea and vomiting with chemotherapy. Aprepitant should be used with a corticosteroid, such as methylprednisolone (Medrol®) or dexamethasone (Decadron®), and a 5-HT3 antagonist, such as:

How Does Aprepitant Work?

Nausea and vomiting are complex processes involving many chemicals in the body and several parts of the body, including the brain and the digestive tract. A chemical called substance P is produced by the body and acts in the brain to cause nausea and vomiting. Substance P exerts its effects by binding to specific receptors in the brain called neurokinin 1 (NK-1) receptors. Aprepitant works by blocking the NK-1 receptors, preventing substance P from binding and causing nausea and vomiting.
Aprepitant works differently from other nausea and vomiting medications. As a result, combining it with other types of nausea or vomiting medications usually provides additional benefit.
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Aprepitant for Nausea or Vomiting

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