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Precautions and Warnings With Aprepitant

Prior to starting a new medication, you should be aware of the drug's precautions and warnings. With aprepitant, these warnings include looking out for possible drug interactions, being aware that aprepitant can make birth control pills less effective, and telling your healthcare provider if you have liver disease or any allergies. You should avoid aprepitant if you are allergic to any components of the drug.

Aprepitant: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking aprepitant (Emend®) if you have:
  • Liver disease, including cirrhosis or liver failure
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you:
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Aprepitant

Warnings and precautions to be aware of prior to taking aprepitant include the following:
  • Aprepitant can interact with a number of other medications (see Drug Interactions With Aprepitant for more information). Some interactions with aprepitant can be life threatening.
  • Aprepitant may make birth control pills less effective, increasing your risk of pregnancy. You should use a back-up method of contraception (such as condoms) during aprepitant treatment and for one month after stopping aprepitant.
  • Aprepitant has not been studied for continuous use and is not intended to be used in this manner.
  • If you have liver disease, your body may not metabolize aprepitant as well as it should. Therefore, you may require extra monitoring by your healthcare provider, and you may need to take a lower aprepitant dosage.
  • Aprepitant is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known (see Emend and Pregnancy).
  • It is not known if aprepitant passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Emend and Breastfeeding).
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