Drug Interactions With Aprepitant

A number of medications may potentially cause drug interactions with aprepitant, including rifamycin antibiotics, tolbutamide, corticosteroids, and certain benzodiazepines. While some interactions can increase or decrease the medicine levels in your blood, others may cause life-threatening reactions. To help prevent aprepitant drug interactions, make sure to tell your healthcare provider about all other medications you are taking.

Aprepitant Drug Interactions: An Overview

Aprepitant (Emend®) can potentially interact with a few other medications. Some of these medicines that may lead to aprepitant interactions include:
 
  • Astemizole (Hismanal®)
  • Certain antibiotics or antifungals, including:
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®)
  • Certain benzodiazepines, including:
o Alprazolam (Xanax®, Xanax® XR)
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Some chemotherapy medications, including:
o Ifosfamide (Ifex®)
o Vinblastine (Velban®)
o Vincristine (Marqibo®, Oncovin®, Vincasar®)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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