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Drug Interactions With Aprepitant

Aprepitant Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when aprepitant is combined with any of the drugs listed above.
 
Astemizole (Hismanal)
Aprepitant should never be taken with astemizole, as life-threatening reactions may occur. While astemizole has been withdrawn from the market in the United States, it may be available in other countries.
 
Certain Antibiotics or Antifungals
Some antibiotics and antifungals can increase the level of aprepitant in your blood, increasing your risk of aprepitant side effects. Talk to your healthcare provider before using these medications together.
 
Certain Benzodiazepines
Aprepitant can increase the level of some benzodiazepines in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your benzodiazepine dosage.
 
Cisapride (Propulsid)
Aprepitant should never be taken with cisapride, as life-threatening reactions may occur. While cisapride has been withdrawn from the market in the United States, it may be available in other countries.
 
Corticosteroids
Aprepitant can increase the level of corticosteroids in your blood. Usually, your healthcare provider will recommend a lower dose of the corticosteroid.
 
Diltiazem
Diltiazem can increase the level of aprepitant in your blood, increasing your risk of side effects. Talk to your healthcare provider before taking diltiazem and aprepitant together.
 
Oral Contraceptives
Aprepitant may make oral contraceptives (birth control pills) less effective, increasing your chance of pregnancy. You should use a back-up method of contraception (such as condoms) during treatment with aprepitant and for one month after the last dose of aprepitant.
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