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Clinical Effects

In studies using aprepitant to prevent nausea and vomiting due to chemotherapy, this medicine was combined with two other medications: ondansetron (Zofran®) and dexamethasone (Decadron®). People who added aprepitant experienced less vomiting, compared to those taking just ondansetron and dexamethasone. However, it did not seem to decrease the chance of nausea.
Aprepitant was also studied for preventing nausea and vomiting after surgery in comparison to ondansetron (Zofran). When compared to ondansetron, aprepitant reduced the chance of vomiting within the first 48 hours after surgery by up to 15.2 percent.

When and How to Take Aprepitant

General considerations for when and how to take this medication include the following:
  • Aprepitant comes in capsule form. It is taken by mouth, usually one hour before chemotherapy or within three hours before surgery. Surgery patients take just one dose, while chemotherapy patients usually take two more doses (in the next two mornings after the first dose). This drug is also available in an injection that can be used in place of the oral dose before chemotherapy.
  • This medication can be taken with or without food. However, you may need to have an empty stomach for surgery. Be sure to ask your healthcare provider if you may take your dose with food.
  • For the medication to work properly, it must be taken as prescribed.

Dosing Information

The dose of aprepitant your healthcare provider recommends will vary, depending on a number of factors, including:
  • Whether you are having surgery or chemotherapy
  • Other medications you may be taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Aprepitant Dosing for more information.)
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