You should talk with your healthcare provider prior to taking aprepitant if you have:
- Liver disease, including cirrhosis or liver failure
- Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Emend and Pregnancy)
- Breastfeeding (see Emend and Breastfeeding)
- Taking oral contraceptives (birth control pills).
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Aprepitant to learn more, including information on who should not take the drug.)
Nausea and vomiting are complex processes involving many chemicals in the body and several parts of the body, including the brain and the digestive tract. A chemical called substance P is produced by the body and acts in the brain to cause nausea and vomiting. Substance P exerts its effects by binding to specific receptors in the brain called neurokinin 1 (NK-1) receptors.
Aprepitant works by blocking the NK-1 receptors, preventing substance P from binding and causing nausea and vomiting. Because this drug works differently from other nausea and vomiting medications, combining the two usually provides additional benefit.