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Ambrisentan Side Effects

Common Side Effects

Ambrisentan has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking ambrisentan were documented and compared with the side effects that occurred in a similar group of people taking a placebo (a "sugar pill" with no active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In these studies, the most common side effects of ambrisentan included:
  • Swelling of the body, especially the hands, legs, ankles, and feet (edema) -- in up to 17 percent of people
  • Nasal congestion -- up to 6 percent
  • Flushing (sudden warmth and redness of the face, neck, and chest area) -- up to 4 percent
  • Inflamed sinuses (nasal passages) -- up to 3 percent.
Some possible ambrisentan side effects have been reported "post-marketing," which means they occurred in the general population after the drug was approved by the U.S. Food and Drug Administration (FDA). Because these potential side effects occurred in people taking the medicine in everyday life, as opposed to in a controlled clinical study, it can be difficult to know for certain whether they were actually caused by ambrisentan or by something else.
Reported post-marketing side effects of ambrisentan have included:
  • Anemia (low red blood cell count)
  • Loss of strength and energy
  • Dizziness
  • Fatigue
  • Heart failure
  • Nausea and vomiting
  • Increases in liver enzymes, which could be a sign of liver damage.

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking ambrisentan or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.

Ambrisentan Drug Information

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