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Clinical Effects of Ambrisentan

Clinical studies have shown that ambrisentan can improve exercise ability in people with PAH. In one study, people who took ambrisentan were able to walk 44 meters farther in 6 minutes, on average, after 12 weeks of treatment. In comparison, those who took a placebo (a "sugar pill" with no active ingredient) walked 8 meters less in 6 minutes after 12 weeks.
Ambrisentan was also shown to slow clinical worsening of PAH in clinical trials. In these studies, people given ambrisentan had less worsening of their condition over 12 weeks, which meant they were less likely to:
  • Need to go the hospital for their PAH symptoms
  • Need additional PAH treatment
  • Stop ambrisentan because their PAH got worse
  • Have a lung transplant or other surgeries for PAH
  • Die.

When and How to Take This Medicine

Some general considerations to keep in mind during treatment with ambrisentan include the following:
  • Ambrisentan comes in tablet form. It is usually taken by mouth once a day.
  • This medication can be taken with or without food. Try taking it with food if it upsets your stomach.
  • You can take ambrisentan any time during the day, but try to take it at the same time each day to keep an even level of the drug in your bloodstream.
  • Swallow ambrisentan whole. Do not crush, cut, chew, or split the tablets.
  • For the medication to work properly, it must be taken as prescribed.

Dosing Information for Ambrisentan

The dose of ambrisentan your healthcare provider recommends may vary, depending on a couple of factors, including:
  • How you tolerate the medicine
  • Other medications you are taking.  
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click Ambrisentan Dosage for more information.)

Ambrisentan Drug Information

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