How Does It Work?Protein kinases are enzymes found in the body that regulate cell function, including cell growth. Afinitor works by blocking the action of a specific protein kinase called the mammalian target of rapamycin (mTOR).
When mTOR does not function properly, as is the case in certain types of cancer and in people with tuberous sclerosis, cells grow and multiply abnormally. mTOR also promotes blood vessel growth into tumors, which supplies cancer cells with nutrients and energy, and gives them a way to spread to other areas of the body.
By inhibiting mTOR, Afinitor stops cancer and tumor cells from growing and multiplying. It also cuts off the blood supply to cancer cells, which may help slow down the spread of the disease.
Is It Safe for Children to Use Afinitor?
Afinitor is approved for use in children with SEGA who are at least one year old. It has not been adequately studied in younger infants with SEGA, or in individuals younger than 18 years old with other conditions. Afinitor comes in special tablets (known as Disperz tablets) that can be mixed with water to make a suspension just before each dose for use in children with SEGA.