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How Does Afinitor Work?

Protein kinases are enzymes found in the body that regulate cell function, including cell growth. Afinitor works by blocking the action of a specific protein kinase called the mammalian target of rapamycin (mTOR).
When mTOR is not functioning properly, as is the case in certain types of cancer and in people with tuberous sclerosis, cells grow and multiply abnormally. mTOR also promotes blood vessel growth into tumors, which supplies cancer cells with nutrients and energy, and gives them a way to spread to other areas of the body.
By inhibiting mTOR, Afinitor stops cancer and tumor cells from growing and multiplying. It also cuts off the blood supply to cancer cells, which may help slow down the spread of the cancer.

When and How to Take It

Some general considerations to keep in mind during treatment with Afinitor include the following:
  • This medication comes in regular tablet form and in Disperz tablet form. The Disperz tablets are combined with water just before each dose to make a suspension. Both forms are taken by mouth, usually once a day.


  • You can take Afinitor with food or on an empty stomach; however, you should take it the same way (either with or without food) every time.


  • For the regular tablets, do not cut, chew, or crush the tablets. Swallow them whole with a glass of water.


  • For the Disperz tablets, carefully follow the package instructions to prepare the suspension, either using an oral syringe or a small cup. If the suspension is not taken within 60 minutes of preparation, it must be discarded.


  • Take this medication at the same time each day to keep an even level in your blood.


  • For Afinitor to work properly, it must be taken as prescribed.
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Afinitor Medication Information

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