Afinitor Drug Interactions
Afinitor Drug Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Afinitor is combined with any of the drugs listed above.
Afinitor may increase the risk for a potentially serious reaction to angiotensin-converting enzyme (ACE) inhibitors known as angioedema. Angioedema causes swelling beneath the skin, usually around the lips and eyes. It can be life-threatening if the throat and tongue swell and block the airway. Seek immediate medical attention if you develop swelling of the face or neck, welts, or breathing problems while taking Afinitor with an ACE inhibitor.
CYP 3A4 Inducer Medications
The liver breaks down Afinitor using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Afinitor with one of these drugs may decrease the level of Afinitor in your body, potentially making it less effective. Your healthcare provider may need to monitor you more closely, and may need to increase your Afinitor dosage, if you take it with a CYP 3A4 inducer.
CYP 3A4 Inhibitor Medications
The liver breaks down Afinitor using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Afinitor with one of these drugs may increase the level of Afinitor in your body, increasing your risk for side effects.
Check with your healthcare provider before taking a CYP 3A4 inhibitor during Afinitor treatment. Some CYP 3A4 inhibitors should not be combined with Afinitor at all. Others may require an adjustment of your Afinitor dose when you first start or stop the CYP 3A4 inhibitor.
Combining Afinitor with denosumab may increase your risk for potentially serious infections. If you take these medicines together, report any signs of infection, such as fever, body aches, and chills, to your healthcare provider.