Afinitor Doses for Brain TumorsThe recommended initial dosage of Afinitor for subependymal giant cell astrocytoma (SEGA), a rare type of brain tumor, will vary, depending on your body surface area, which is normally calculated using your height and weight.
Your healthcare provider will monitor your Afinitor blood levels two weeks after you start treatment and two weeks after each change in dose. If necessary, your healthcare provider will adjust your dose, by no more than 2.5 mg every two weeks (for regular tablets) or 2 mg every two weeks (for the Disperz tablets), to get you to a target blood level of 5 to 10 nanograms per milliliter (ng per mL). Lower or higher levels may be used in certain people based on tolerability and tumor response. Blood levels higher than 15 ng per mL are not recommended.
If the lowest available strength (2 mg) is too high, then Afinitor can be given every other day to help achieve the proper dosage.
The recommended dose of Afinitor for advanced breast cancer is 10 mg once daily. For this use, Afinitor should be combined with exemestane (Aromasin®).
If serious or intolerable side effects occur, the drug may need to be stopped or reduced to 5 mg daily.
The recommended dosage for people with mild liver disease is 7.5 mg a day. The dose may be reduced to 5 mg a day if 7.5 mg is not tolerated. The recommended dosage for people with moderate liver disease is 5 mg daily. The dose may be reduced to 2.5 mg a day if 5 mg is not tolerated. People with severe liver disease should be given no more than 2.5 mg of Afinitor a day.
Higher or lower amounts may be used in people taking certain medications known to interact with Afinitor (see Afinitor Drug Interactions for more information).